Oral Diseases

Team leader

Teresa Pinho

Major interests

The mission of this research line is to develop and apply research to understand, prevent, diagnose, and treat diseases affecting the orofacial region.

The specific objectives are:

i) To characterize the periodontal disease

Research activities include: antimicrobial potential of the Leukocyte-Platelet Rich Fibrin (L-PRF) in dentistry; association of periodontitis with systemic diseases; 16S rDNA metagenomic analysis for an oral infectious-inflammatory scale; new markers of peri-implant diseases and periodontitis; laser as an adjunct treatment in Peri-implantitis and periodontitis.

ii) To characterize the relationship between temporomandibular disorders with headaches

Research activities include: genome-wide approach to assess association between the two disorders; Physiotherapy in pain reduction and function improvement.

iii) To study congenitally missing teeth

Research activities include: miRNA profiling in patients with maxillary lateral incisor agenesis; minimally invasive rehabilitation of missing tooth.

iv) To improve attachments used with implant supported denture

Research activities include: new attachment to improve durability, reliability and retention capacity of implant supported denture.

v) To promote public oral health knowledge and good practices

Activities include: organization of promotion activities at the north of Portugal; public awareness and knowledge of dental/oral practices and diseases (hygiene, cancer, periodontitis, caries), namely among school children.

Current Projects

Asociación de la periodontitis crónica con las enfermedades sistémicas: análisis de la interacción microbioma-hospedador a nivel oral y sistémico.

              
        Asociación de la periodontitis crónica con las enfermedades sistémicas: análisis de la interacción microbioma-hospedador a nivel oral y sistémico.   
Principal Investigator: 
Inmaculada Tomás Carmona 
Leader Institution: 
Universidade de Santiago de Compostela
Funding entity: 
Consellería de Cultura, Educación e Ordenación Universitaria
Programe: 
Budget: 
Period covered: 
2018-2020
Abstract: 
Research Team: 
Marta Relvas

C490122012-00080154: Estudo Clínico e genético das cefaleias primárias e suas comorbilidades mais relevantes

              
        C490122012-00080154: Estudo Clínico e genético das cefaleias primárias e suas comorbilidades mais relevantes   
Principal Investigator: 
José Pereira Monteiro
Leader Institution: 
IBMC-i3S
Funding entity: 
FCT (02/SAICT/2017)
Programe: 
Budget: 
Period covered: 
2018-2020
Abstract: 
Research Team: 
Teresa Pinho, Maria Paço, António Sequeiros, Miguel Ferreira, Joana Silva, Carolina Lemos, Alda Sousa, Isabel Alonso, Diana Santos, João Neto

OrthoAlign-PI-4RL-IINFACTS-2019: Orthodontic tooth movement: biomechanics involved on aligners appliances.

              
        OrthoAlign-PI-4RL-IINFACTS-2019: Orthodontic tooth movement: biomechanics involved on aligners appliances  
Principal Investigator: 
Teresa Pinho (teresa.pinho@iucs.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
PI-4RL_2019
Budget: 
16.900€
Period covered: 
03/2019 - 02/2020
Abstract: 
The search for means/strategies that may subserve or enhance orthodontic movement is a current reality. Mechanical vibration and photobiomodulation (PBM) are non-invasive methods that can be applied with orthodontic treatment (OT) in order to increase the tooth movement rate, although the fundamental basis of its mechanisms of action and its predictable use remain unclear. It is well known that during OT, several therapeutic steps may lead to the following temporary alterations: reduced mouth opening, reduced bite force (BF), chewing performance interferences and appearance of muscle or joint pain. In this project we will focus on the biomechanics of clear aligners (CA) technique. We aim to understand the biomechanics involved in orthodontic tooth movement and to evaluate the possible effect of vibration and PBM on the acceleration of orthodontic tooth movement, by using customized medical devices. We also intend to verify the performance of mastication, pain pressure threshold in chewing muscles, and the incidence of Temporomandibular Disorders (TMDs), when using current orthodontic treatments such as CA in healthy individuals, without any previous signs or symptoms of TMDs.
Research Team: 
Teresa Pinho (PI), Susana Coimbra (Co-PI), Luís Moutinho Monteiro (Co-PI), Vera Almeida (Co-PI), Rui Azevedo, Virgínia Gonçalves, Vanessa Marcelino, Selma Pascoal, Óscar Carvalho, Mariana Santos, Mara Paço, Maria João Calheiros Lobo, Maria Elizabeth Tiritan, Lígia Rocha, José Carlos Ferreirinha, Filipe Samuel, Duarte Rocha, Cristina Manzanares Cespedes, António Sérgio Guimarães, Aline Gonçalves, Alexandra Costa, Albina Resende

DEBORA-PI-3RL-IINFACTS-2019: Disease, Emotion and Wellbeing: Regulated Organization of Action.

              
        DEBORA-PI-3RL-IINFACTS-2019: Disease, Emotion and Wellbeing: Regulated Organization of Action  
Principal Investigator: 
José Carlos Rocha (jose.rocha@iucs.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
PFT_2019
Budget: 
4.000€
Period covered: 
03/2019 - 02/2020
Abstract: 
The emotional mediated processes between negative life-events and the actions enabling a positive outcome are capable to prevent problems and to promote happiness in societies. This pathway has been used to overcome the most challenging wellbeing difficulties, with known extreme consequences in health, considered today the most powerful modifiable disease risk factors, with known effects on relationships and economical productivity impairment. This knowledge expanded largely on last years and opened the way for new organised approaches, fine-tuned to address very specific predictors. To act we need to know exactly the best options, there is a concomitant premise of understanding the underlying factors, never disclosed nor measured. This project aims to develop or to adapt a set on very new instruments that are possible candidate variables to produce such extreme positive effect. The operational side of the project has focus on the development of twenty different instruments, some absolutely new, some very recently developed, some being developed on worldwide ongoing efforts.
Research Team: 
José Carlos Rocha (PI), Ana Teixeira (Co-PI), Maria Amélia Pçao (Co-PI), Manuela Leite, Sónia Remondes Costa, Paula Chaves, Teresa Pinho, Sara Lima, Ricardo João Teixeira, Joana Soares, Vera Almeida

CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019: Chiral derivatives of xanthones and flavonoids: synthesis and biological activity evaluation.

              
        CHIRALBIOACTIVE-PI-3RL-IINFACTS-2019: Chiral derivatives of xanthones and flavonoids: synthesis and biological activity evaluation.  
Principal Investigator: 
Maria Elizabeth Tiritan (elizabeth.tiritan@iucs.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
PI-3RL_2019
Budget: 
15.000€
Period covered: 
03/2019 - 02/2020
Abstract: 
Xanthone derivatives and flavonoids demonstrated great potential in diverse biological activities. They are interesting chemical building blocks for preparation of new derivatives with association with chiral moieties allowing to enlarge the chemical diversity and to explore the role of the molecular stereochemistry. This work aim to synthesize a new library of chiral derivatives of xanthones (CDXs) and flavonoids (CDFs) by coupling to enantiomerically pure amino alcohols, amines, proteinogenic amino esters and amino acids. Diverse biological activities of the CDXs and CDFs will be evaluated comprising, anti-inflammatory, anti-infective and antitumor. Resistance to treatment associated with cancer therapy is often caused by the expression of efflux pumps in cancer cells, we will determine if these compounds are P-glycoprotein (Pgp) substrates, by using a MDR1-transformant yeast as host. Furthermore, their effectiveness on tumor cells will be studied through high-throughput assays of viability. As the bioenergetic deregulation is one of the emergent cancer hallmarks, their effect on metabolic parameters like lactate and glucose will also be assessed.
Research Team: 
Maria Elizabeth Tiritan (PI), Odília Queirós (Co-PI), Cristina Coelho (Co-PI), Alexandra Costa, Paolo De Marco, Sandra Quinteira, Sónia Marisa Machado, Carla Fernandes, Madalena Pinto, Carlos Afonso, Emilia Sousa, Honorina Cidade, Marta Correia da Silva, Virginia Gonçalves, Helena Susana da Costa Machado Ferreira, Nuno João Meleiro Alves das Neves, Sara Filipa Fontoura Vieira, Hassan Bousbaa, Patrícia Silva, Joel Pedrosa, Andrea Cunha, Juliana Faria, Joana Barbosa, Orquídea Lurdes Alves Resende

IMPLDEBRIS-PI-3RL-IINFACTS-2019: Biological assessment of debris from oral implants.

              
        IMPLDEBRIS-PI-3RL-IINFACTS-2019: Biological assessment of debris from oral implants.  
Principal Investigator: 
Hassan Bousbaa (hassan.bousbaa@iucs.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
PI-3RL_2019
Budget: 
15.000€
Period covered: 
03/2019 - 02/2020
Abstract: 
Dental implants and orthodontic mini-implants manufactured from titanium and stainless-steel alloys are routinely used in clinical practice. Most orthodontic mini-implants are manufactured from Titanium alloy (Ti6Al4V) or stainless-steel alloys although several constituent elements of these alloys reveal a mutagenic or carcinogenic potential. The aim of the present study is to carry out an in vitro cytotoxic analysis in order to assess the biological safety of particles released from titanium alloys and stainless-steel orthodontic mini-implants. During the first year of the project, these particles will be characterized in terms of size and morphology, and their cytotoxic effect analyzed in terms of cell viability and permeability. During the second year, the particles will be characterized in terms of cellular internalization mechanism and genotoxicity potential. It is expected that this study will contribute to clarify whether titanium wear-derived particles released in the oral environment are associated with harmful side effects in the human body.
Research Team: 
Hassan Bousbaa (PI), Primavera Santos (Co-PI), Bruno Sarmento (Co-PI), Flávia Sousa, Rui Moura, Andreia Almeida, Antonio Pedro Fonseca, Júlio César Matias de Souza, Ana Henriques, Patrícia Silva, Joel Pedrosa, Henrique Borges, Ana Borges

MVOS-PFT-IINFACTS-2019: Microbiological validation of an oral health scale of infectious-inflammatory potential through 16S rDNA metagenomic techniques

              
        MVOS-PFT-IINFACTS-2019: Microbiological validation of an oral health scale of infectious-inflammatory potential through 16S rDNA metagenomic techniques  
Principal Investigator: 
Marta Relvas (marta.relvas@iucs.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
PFT_2019
Budget: 
3.000€
Period covered: 
03/2019 - 02/2020
Abstract: 
Little has been published in the dental literature on the combination of distinct variables in the design of oral health scales. Particular interest in the idea of representing the oral health status in a single numerical value arose with the development of “Periodontal Medicine”, which aims to establish correlations between infectious/inflammatory disorders of the oral cavity and the appearance of certain systemic diseases. In this thesis, we propose a new global oral health scale that establishes a single value for the infectious potential of the oral cavity, which has its clinical expression in the form of local and focal infections. The scale incorporates dental and periodontal variables organised according to objective and tested indices that reflect to a certain degree the presence of the principal infectious disorders of the oral cavity, caries and periodontal disease. The different grades of the scale have been correlated with the presence and concentration of various bacterial species of the salivary flora.
Research Team: 
Marta Relvas, José Júlio Pacheco, Filomena Salazar, Cristina Cabral, Inmaculada Tomás

LASERORAL-CESPU-2018: Evaluation of Biologic effects of Laser Treatment of Benign and Potentially Malignant Diseases in Oral Cavity.

              
        LASERORAL-CESPU-2018: Evaluation of Biologic effects of Laser Treatment of Benign and Potentially Malignant Diseases in Oral Cavity  
Principal Investigator: 
Luís Monteiro (luis.monteiro@iucs.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
PI4AC_2018
Budget: 
5000€
Period covered: 
2018-2019
Abstract: 
everal tissue interactions could be observed in oral tissues. At high power level, lasers can ablate and vaporize the tissues promoting not only the elimination or cut of a tissue but also to destroy bacteria. There is increasing popularity of high-power lasers for surgical debridement and antimicrobial therapy in the management of peri-implantitis and periodontal therapy. A recent method of low energy uses Er:YAG laser to contract oropharynx and decrease snoring. It would be necessary to evaluate the biological effect on fibroblasts and collagen to explain the mechanisms of this proposed treatment. The general objective is to understand the biological effect of Lasers in cells of lesions or diseases of the oral cavity. Our longterm goal is to explore the potential to use lasers in the treatment of several diseases of oral cavity. We will analyse the effect Laser in cells lines and evaluate proliferative markers, apoptotic markers and hypoxia markers. We will also perform a clinical prospective study of the use of Lasers groups of patients treated in CESPU Clinic. We will analyse the outcome in terms of recurrence/success of treatment or malignant transformation.
Research Team: 
Luís Monteiro, Fernanda Garcez, José Manuel Mendes, Filomena Salazar, José Júlio Pacheco, Leonor Delgado, Barbas do Amaral, Hassan Bousbaa

TMD&Hdache-CESPU-2018: Temporomandibular disorders, headache and psychosocial factors: a characterization and genetic study.

              
        TMD&Hdache-CESPU-2018: Temporomandibular disorders, headache and psychosocial factors: a characterization and genetic study  
Principal Investigator: 
Maria Amélia Paço (maria.paco@ipsn.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
PI4AC_2018
Budget: 
5000€
Period covered: 
2018-2019
Abstract: 
TMDs is the most common chronic orofacial pain condition, being accepted that it has a multifactorial etiology with several contributing factors that may be the cause or contribute to its chronicity, namely neurobiological, neuromuscular, biomechanical and psychosocial factors. With this project, we aim to deepen the link between TMDs and associated comorbidities as primary headaches, regarding the shared common mechanisms between the two pathologies. We will apply a Next Generation approach to explore genetic variations that may act on the pathogenesis of TMDs and migraine and we expect to provide new insights regarding shared genetic risk for these conditions. Understanding the mechanisms underlying migraine and TMDs pathophysiology could lead to the development of more effective and better-tolerated therapeutic approaches to avoid the overlay of painful events. Furthermore, a deepest understanding about the presence of psychosocial factors in these patients may contribute to more efficient interventions, in the light of bio-psycho-social model.
Research Team: 
Maria Amélia Paço, Soraia Telha, Margarida Pacheco, Vera Almeida, José Carlos Rocha, Paula Chaves, Júlio Fonseca, José Alberto Coelho, Vanessa Marcelino, Miguel Ferreira, Carolina Lemos, José Monteiro, Teresa Pinho

HT-BAGP-CESPU-2018: Human traces from car inner surfaces: Broadening the application of genetic policing.

              
        HT-BAGP-CESPU-2018: Human traces from car inner surfaces: Broadening the application of genetic policing.  
Principal Investigator: 
Daniel Pérez Mongiovi (daniel.mongiovi@iucs.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
PI4AC_2018
Budget: 
3000€
Period covered: 
2018-2019
Abstract: 
Forensic sciences promote the interaction of different scientific areas, contributing to the good application of justice in the best interest of the citizen. Within this multidisciplinary science, the lofoscopy and genetic domains are highly relevant since they analyse evidence that lead to the unequivocal identification of individuals involved in illicit acts. The fingerprint traces, revealed in the most diverse surfaces, do not always have an identification value, due to limiting factor, such as the fact that the minimum twelve characteristic points that allow an absolute certainty of identity may not be visible. However, fingerprints can be a source of DNA allowing the elaboration of the genetic profiles that will lead to the identification of individuals. As highlighted by police forces, lofoscopy is limited on the retrieval of positive matches with individuals in some types of matrices, namely in car steering wheels. As so, the current project mainly intends to evaluate the possibility of using these two scientific domains being synergistic and promising tools in a real forensic scenario involving vehicles.
Research Team: 
Daniel Pérez Mongiovi, Sara Moreira, Ricardo Dinis, Pedro Correia, Patrícia Campos, Maria Begoña Criado, Laura Cainé, Áurea Carvalho, Ana Pereira

MLIA-CESPU-2018: Maxillary lateral incisor agenesis: chemical-mechanical behavior of new composite resins and monolithic ceramics in minimally invasive aesthetic rehabilitation.

              
        MLIA-CESPU-2018: Maxillary lateral incisor agenesis: chemical-mechanical behavior of new composite resins and monolithic ceramics in minimally invasive aesthetic rehabilitation.  
Principal Investigator: 
Teresa Pinho (teresa.pinho@iucs.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
OralDiseases_2018
Budget: 
4000€
Period covered: 
2018-2019
Abstract: 
The maxillary lateral incisor agenesis (MLIA) brings orthodontic and prosthetic problems of lifelong maintenance, family counseling, complex treatment plans and an interdisciplinary approach. The MLIA can be treated by closing or opening spaces, and the cases are finished with composite resin additions (RC) or dental implants or resin bonded bridgework (RBB), respectively, after orthodontics, based on biological parameters. Both options require time-stable adhesive joints coupled with materials of adequate mechanical performance. We can minimize errors, reduce faulty predictions, and improve results with virtual prototyping using finite element analysis (FE), based on computed tomography (CT). FE analysis of pressure / strain on dental structure and biomaterials, varying tooth preparation designs and types of resin or ceramic reconstruction, can be made. It is intended to analyze in vitro and monitor the Bisphenol-A in CR and PAR to be used in the finalization of MLIA cases in young patients and to create an efficient virtual model to compare different joints, designs and materials.
Research Team: 
Teresa Pinho, João Calheiros-Lobo, Mafalda Calheiros-Lobo, Joana Duarte, Duarte Rocha, Ricardo Carbas, Jorge Belinha, Maria Elizabeth Tiritan, Lucas Silva, Lígia Rocha, Maria João Calheiros-Lobo

Agenesias-tratamento_CESPU_2017: Treatment of maxillary lateral incisor agenesis: close vs open space.

              
        Agenesias-tratamento_CESPU_2017: Treatment of maxillary lateral incisor agenesis: close vs open space.   
Principal Investigator: 
Teresa Pinho (teresa.pinho@iucs.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
OralDiseases 2017
Budget: 
4.000,00 €
Period covered: 
2017-2018
Abstract: 
Congenitally missing lateral incisors creates an esthetic problem with specific orthodontic and prosthetic considerations. Our goal is to analyse in vivo and in vitro the clinical performance of esthetical in MLIA orthodontic cases, as well as the treatment with direct composite additions and with resin-bonded bridgework in patients with dental agenesis of the maxillary lateral incisor, following orthodontic treatment to close or open the missing tooth space. Furthermore, we aim to develop an efficient virtual prototyping method to compare different preparation designs of resin-bonded bridgework. Bisphenol-A (BPA) has recently been shown to have endocrine disrupter action as an environmental hormone. For this reason, we also intend to monitor the presence of this monomer in artificial saliva storage and biological fluids collected before and after adhesive rehabilitation of young patients. We expect to obtain not only satisfactory esthetical and functional results with both techniques, but also consider them as a non-provisional approach.
Research Team: 
Lígia Rocha, Elizabeth Tiritan, Ana Gomes, Filomena Dias, Tomás Ribeiro, Eugénie Carneiro, Viviana Carneiro, Ricardo Carbas, Daniela Paiva, Maria João Lobo, Paula Lobo

DTM_Headaches_CESPU_2017: Temporomandibular disorders: Interrelationship between craniocervical posture, malocclusion, psychological factors and determinants of headache - Continuation.

              
        DTM_Headaches_CESPU_2017: Temporomandibular disorders: Interrelationship between craniocervical posture, malocclusion, psychological factors and determinants of headache - Continuation.  
Principal Investigator: 
Teresa Pinho (teresa.pinho@iucs.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
PI4AC 2017
Budget: 
6.000,00 €
Period covered: 
2017-2018
Abstract: 
TMD is the most common chronic orofacial pain condition, characterized by changes in the temporomandibular joint, the masticatory muscles and surroundig structures, or both. It is considered to have a multifactorial etiology with several contributing factors that may be the cause or contribute to its chronicity, namely neurobiological, neuromuscular, biomechanical and psychosocial factors. The literature has shown a relationship between craniomandibular and craniocervical systems, showing a relation between TMD and postural factors. Concomitantly with TMD, there have been described several comorbidities associated with pain, like headache, whose pathophysiology seems to indicate the existence of common mechanisms. Psychosocial factors also seem to be related to TMD. For these reasons, it is important to study the relationship between these variables.
Research Team: 
Joana Tavares, Maria Paço, Vera Almeida, Carolina Lemos, José Coelho, Sofia Rosas, Margarida Pacheco, José Alberto Duarte, David Matos, Cristina Cespedes, Teresa Vale, Paula Chaves, Alda Sousa, Miguel Alves-Ferreira, Mafalda ALves

IPGTROF_CESPU_2017: In vitro study of the invasive capacity and survival of Porphyromonas gingivalis (strain ATCC 33277) on trophoblasts from the first and third gestational trimester.

              
        IPGTROF_CESPU_2017:  In vitro study of the invasive capacity and survival of Porphyromonas gingivalis (strain ATCC 33277) on trophoblasts from the first and third gestational trimester.   
Principal Investigator: 
Cristina Maria Leal Coelho (cristina.coelho@ipsn.cespu.pt)
Leader Institution: 
CESPU
Funding entity: 
CESPU
Programe: 
OralDiseases 2017
Budget: 
4.000,00 €
Period covered: 
2017-2018
Abstract: 
Increasing evidence suggests that maternal periodontal disease is associated with gestational outcomes, including low birth weight and preeclampsia. One of the major periodontal pathogen, Porphyromonas gingivalis, is a Gram-negative anaerobe that can invade and survive within epithelial cells, disrupts cytokine expression and increases cell proliferation while suppressing apoptosis. All of these properties could potentially disrupt homeostasis in the placental tissues. It is also potentially important that,during the first 10-12 weeks of gestation, the placenta is in a state of physiological hypoxia, which would facilitate growth of anaerobes such as P. gingivalis. Although several authors have isolated P. gingivalis from the placenta of pregnant women with preeclampsia, little is known about the ability of this bacterium to infect and survive in trophoblasts. The objective of this study is to evaluate in vitro the invasiveness and survival of P. gingivalis in human trophoblastic cultures of the first and third trimester of gestation.
Research Team: 
Orquídea Santos, José Júlio Pacheco

Publications Highlights

Zacca, Rodrigo; Azevedo, Rui; Ramos, Valdir R. Jr; Abraldes, José A.; Vilas-Boas, João P.; Castro, Flávio Antônio de Souza; Pyne, David B.; Fernandes, Ricardo J. (2019). Biophysical Follow-up of Age-Group Swimmers During a Traditional Three-Peak Preparation Program. The Journal of Strength & Conditioning Research XX(X) (10.1519/JSC.0000000000002964)

Bucchi C, del Fabbro M, Arias A, Fuentes R, Mendes JM, Ordonneau M, Orti V, Manzanares-Céspedes MC (2019). Multicenter study of patients’ preferences and concerns regarding the origin of bone grafts utilized in dentistry. Patient Preference and Adherence. 2019 (13), 179-185.

Zacca, R.; Azevedo, R.; Figueiredo, P.; Vilas-Boas, J.P.; Castro, F.A.S.; Pyne, D.B.; Fernandes, R.J. (2019). VO₂FITTING: A Free and Open-Source Software for Modelling Oxygen Uptake Kinetics in Swimming and other Exercise Modalities. Sports 2019, 7, 31.

Zacca, R., Toubekis, A., Freitas, L., Silva, A.F., Azevedo, R., Vilas-Boas, J.P., Pyne, D.B., Castro, F. A.de S. & Fernandes, R.J. (2019). Effects of detraining in age-group swimmers performance, energetics and kinematics, Journal of Sports Sciences, DOI: 10.1080/02640414.2019.1572434

Gomes AF, Pinho T. (2019). Esthetic perception of asymmetric canines treated with space closure in maxillary lateral incisor agenesis. Int J Esthet Dent. 2019;14(1):30-38. PMID: 30714052.

Manuel Mendes, J., Souza, L., Neves, L., Aroso, C., & Sérgio Silva, A. (2019). Study of Complications Associated with Placement of Overdentures on Implants. CPQ Dentistry, 1(4), 01-20.

Monteiro L, Delgado ML, Garcês F, Machado M, Ferreira F, Martins M, Salazar F, Pacheco JJ. (2019). A histological evaluation of the surgical margins from human oral fibrous-epithelial lesions excised with CO2 laser, Diode laser, Er:YAG laser, Nd:YAG laser, electrosurgical scalpel and cold scalpel. Med Oral Patol Oral Cir Bucal. 2019 Mar 1;24(2):e271-e280. doi: 10.4317/medoral.22819.

Silva, A.S., Sá, J. de, Aroso, C.M., Santos, E, Neves, L., and Mendes, J.M. (2018). Rehabilitation of an atrophic jaw with three short implants and a customized milled bar overdenture. Australian Medical Journal 2018;11(12):565–572

Machado, S. C., Manzanares-Céspedes, M. C., Ferreira-Moreira, J., Ferreira-Pacheco, J. J., Rompante, P. A., & Ustrell-Torrent, J. M. (2018). A sample of non-nutritive sucking habits (pacifier and digit) in portuguese children and its relation with the molar classes of angle. Journal of clinical and experimental dentistry, 10(12), e1161-e1166. doi:10.4317/jced.55284

Jonsson L., Magnusson TE., Thordarson A 2 , Jonsson T., Geller F 3 , Feenstra B., Melbye M., Nohr EA., Vucic S., Dhamo B., Rivadeneira F., Ongkosuwito EM., Wolvius EB., Leslie EJ., Marazita ML., Howe BJ., Moreno Uribe LM., Alonso I., Santos M., Pinho T., Jonsson R. , Audolfsson G. , Gudmundsson L., Nawaz MS., Olafsson S., Gustafsson O., Ingason A., Unnsteinsdottir U., Bjornsdottir G., Walters GB., Zervas M., Oddsson A., Gudbjartsson DF., Steinberg S., Stefansson H., & Stefansson K. (2018). Rare and Common Variants Conferring Risk of Tooth Agenesis. Journal of Dental Research. Jan 1:22034517750109.

Zacca R; Azevedo R.; Chainok P.; Vilas-Boas J.P.; Castro F.A. de S. ; Pyne D.B. ; Fernandes R.J. (2018). Monitoring Age-Group Swimmers Over a Training Macrocycle: Energetics, Technique, and Anthropometrics. Journal of Strength and Conditioning Research. Publish Ahead of Print():, AUG 2018

Gomes AF, Pinho T. (2018). Esthetic perception of asymmetric canines treated with space closure in maxillary lateral incisor agenesis. International Journal Esthetic Dentistry (in press).

Lamas C, Lavall A, Pinho T. (2018). Position and eruption of permanent maxillary canine in cases of maxillary lateral incisor agenesis in mixed dentition. Journal of Clinical Pediatric Dentistry. 42(3);240-246.

Ribas J, Paço M; Pinho T. (2018). Perception of facial aesthetics by different observers panels in Class II with mandibular retrusion. International Journal Esthetic Dentistry 13(2):208-219.

Aroso C., Silva AS., Ustrell R., Mendes JM., Braga AC., Berastegui E., & Escuin T (2016). Effect of abutment angulation in the retention and durability of three overdenture attachment systems: An in vitro study. J Adv Prosthodont. 8(1):21-29.

Relvas M., Tomás I., Casares-De-Cal Mde L., & Velazco C. (2015). Evaluation of a new oral health scale of infectious potential based on the salivary microbiota. Clinical Oral Investigation. Apr 19(3), 717-28.

Alves-Ferreira M., Pinho T., Sousa A., Sequeiros J., Lemos C., & Alonso I. (2014). Identification of genetic risk factors for maxillary lateral incisor agenesis. Journal of Dental Research, 93 (5), pp. 452-458.

Mesquita B., Gonçalves M.J., Pacheco P., Lopes J., Salazar F., Relvas M., Coelho, C., Pacheco J.J., & Velazco, C. (2014). Helicobacter pylori identification: A diagnostic/confirmatory method for evaluation. Current Microbiology, 69 (3), pp. 245-251.

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