Drug Research

Major interests


The mission of this research line is to discover biologically active molecules, safely and efficiently target bioactive compounds, and develop analytical methods for determination of pharmaceuticals in biological and environmental matrices. 
 
The specific objectives are:
i) to screen for bioactive compounds
Research activities include: screening for old and new synthetic compounds with therapeutic potential; elucidation of the mechanisms of activity and preclinical assays of leading compounds.
 
ii) to develop safe and efficient delivery systems
Research activities include: new drug delivery nanosystems for antitumoral drugs; f characterization and exploration of food-grade bacteria able to produce bioactive conjugated fatty acids (CLA, CLNA).
 
iii) to develop efficient chromatographic analytical methods
Research activities include: development of efficient chromatographic analytical methods for preparation and analysis of enantiomers of pharmaceuticals and illicit chiral substances; assessment of their ecotoxicological effects on aquatic species.
 
iii) to identify variables that influence adherence to topical treatment
Research activities include: Guidelines for adequate use of topical treatment amongst Portuguese patients with chronic dermatoses; development of therapeutic monitoring tools.
 
iv) disseminate good practices to promote adherence to treatment with topical medicines
Activities include: disseminating good practices at community pharmacies to promote adherence to and effectiveness of treatment with topical medicines; information and education of pharmacists and patients. 

Current Projects


 

Publications Highlights


Castro R., Cavaleiro F.I., Rangel L.F, Rocha S., Severino R., Casal G., & Santos M.J. (2018). Myxozoan parasites of the European sea bass, Dicentrarchus labrax (Teleostei: Moronidae): Correlates of infections at the micro- and macroenvironment scales. Aquaculture 485: 17-24

Silva MF, Ribeiro C, Gonçalves VMF, Tiritan ME, Lima Á. Liquid chromatographic methods for the therapeutic drug monitoring of methotrexate as clinical decision support for personalized medicine: A brief review. Biomed Chromatogr. 2018; 32(5):e4159.

Tiraitan, M.E., Fernandes, C., Maia, A.S., Pinto, M., Cass, Q.B. (2018). Enantiomeric ratios: Why so many notations? Journal of Chromatography A. 2018. In press

Teixeira A., Oliveira C., Teixeira M., Gaio AR., Sousa Lobo JM., Almeida IF., & Almeida V. (2017). Development and validation of a novel questionnaire for adherence with topical treatments in psoriasis, QATOP. Am J Clin Dermatol. Aug;18(4):571-581.

Henriques A.C., & De Marco P.(2015). Methanesulfonate (MSA) catabolic genes from marine and estuarine bacteria. PLoS One 10(5), e0125735.

Fernandes, C., Masawang, K., Tiritan, M.E., Sousa, E., De Lima, V., Afonso, C., Bousbaa, H., Sudprasert, W., Pedro, M., Pinto, M.M. (2014). New chiral derivatives of xanthones: Synthesis and investigation of enantioselectivity as inhibitors of growth of human tumor cell lines. Bioorganic and Medicinal Chemistry, 22 (3), pp. 1049-1062.

Ribeiro A.R., Santos L.H.M.L.M., Maia A.S., Delerue-Matos C., Castro P.M.L., & Tiritan M.E. (2014). Enantiomeric fraction evaluation of pharmaceuticals in environmental matrices by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A, 1363, pp. 226-235.

  

Drug Research Team


PhD Members

PhD Students

MSc Students

Research Fellowship

Volunteers

Research Technician

Collaborators