The search for means/strategies that may subserve or enhance orthodontic movement is a current reality. Mechanical vibration and photobiomodulation (PBM) are non-invasive methods that can be applied with orthodontic treatment (OT) in order to increase the tooth movement rate, although the fundamental basis of its mechanisms of action and its predictable use remain unclear. It is well known that during OT, several therapeutic steps may lead to the following temporary alterations: reduced mouth opening, reduced bite force (BF), chewing performance interferences and appearance of muscle or joint pain. In this project we will focus on the biomechanics of clear aligners (CA) technique. We aim to understand the biomechanics involved in orthodontic tooth movement and to evaluate the possible effect of vibration and PBM on the acceleration of orthodontic tooth movement, by using customized medical devices. We also intend to verify the performance of mastication, pain pressure threshold in chewing muscles, and the incidence of Temporomandibular Disorders (TMDs), when using current orthodontic treatments such as CA in healthy individuals, without any previous signs or symptoms of TMDs.