Colorectal Cancer Spheroid Model to Assess the Biocompatibility and Anticancer Properties of Nanoparticles


24 de setembro, 2020 | 12h00 | Webinar – Plataforma ZOOM

Resumo da apresentação:


Colorectal cancer (CRC) is the third most common and the second deadliest type of cancer worldwide, urging the development of more comprehensive models and of more efficient treatments. Although the combination of nanotechnology with chemo- and immuno-therapy has represented a promising treatment approach, its translation to the clinic has been hampered by the absence of cellular models that can provide reliable and predictive knowledge about the in vivo efficiency of the formulation. Thus, a 3D model based on CRC multicellular tumor spheroids (MCTS) model was developed by combining epithelial colon cancer cells (HCT116), human intestinal fibroblasts and monocytes. Polymeric nanoparticles loaded with chemotherapeutics were produced and tested both in 2D cultures and in the MCTS 3D model.

Dr. Tomás Bauleth-Ramos holds a MSc in Pharmaceutical Sciences (2014, University of Coimbra, Portugal) and a Ph.D. in Biomedical Sciences (2020) from Instituto de Ciências Biomédicas Abel Salazar (ICBAS), University of Porto (Portugal) in collaboration with Harvard University (USA) and the University of Helsinki (Finland). As of September 2020, he is author of 10 peer-reviewed journal articles (3 as first author), 2 book chapters, 9 presentations at scientific meetings, with over 260 citations. His scientific interests are related to the development of nanosystems for combined cancer chemo- and immunotherapy and the development of 3D in vitro cell culture models to assess the biocompatibility and efficacy of the developed therapies.


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IINFACTS - Instituto de Investigação e Formação Avançada em Ciências e Tecnologias da Saúde CBAS_4Ed. - Programa Doutoral em Ciências Biológicas Aplicadas à Saúde do IUCS