Resumo da apresentação:

The human body reacts to injurious stimuli by mounting an inflammatory response. In its acute phase, transvascular extravasation of fluid, plasma proteins and leukocytes occur in the microvasculature of the injured tissue. Inappropriate leukocyte infiltration into tissues associated with stroke, multiple sclerosis, obesity, and other inflammatory disorders have been postulated to cause tissue dysfunction.

The role of vascular endothelial cells as a regulatory organ in immunity and haemostasis has become well established in the last two decades. At sites of injury and inflammation, endothelium becomes locally “activated”. Visualization of leukocyte–endothelial cell interactions in vivo, by intravital microscopy, in inflamed vessels has revealed that leukocytes must first tether and roll along the venule before they can firmly adhere and emigrate out of the vasculature.

The central nervous system is considered an immunologically privileged site due to the presence of the endothelial blood–brain barrier (BBB), which, under physiological conditions, protects against leukocyte traffic into the CNS. However, during inflammatory conditions of the CNS, such as Multiple Sclerosis, large numbers of mononuclear cells gain access to the CNS. Migration of leukocytes through the BBB represents a critical pathogenetic event in the initiation of CNS inflammation.

During the lecture, previous and recent data related to molecular and cellular process (in vivo leukocyte-endothelium interactions) associated to different neuroinflammatory contexts (sepsis and MS) will be presented. The importance of using intravital microscopy technique to understand leukocyte trafficking and other vascular events will be also highlight.

Biography:
She completed her bachelor degree in Immunology & Biochemistry/Biological Sciences/ICB/UFMG and her PhD in Molecular Biology and Physiology Program at Universidad de Valladolid (Valladolid/Spain/Supervisor Dr Mariano Sanchez Crespo). She also was postdoctoral fellow at Cleveland Clinic, Lerner Research Institute (Cleveland, Ohio, USA, Supervisor Dr Damir Janigro); Instituto de Biologia y Genética Molecular (IBGM)/Universidad de Valladolid (Spain/Supervisor Maria Luiza Nieto), and also at Immunology Group/Health Science Centre/University of Calgary (Calgary, Canada/Supervisor Dr Paul Kubes). She is currently Associate Professor IV of the Department of Physiology and Biophysics, and sub-coordinator of the Professional Master's Program in Teaching Biology (PROFBIO) / ICB / UFMG. She got national and international awards at scientific events and from 1st Americas School of Neuroimmunology (ASNI/Calgary, Canada), and also received the title of Honor Professor of XIII Class of Nutrition Undergraduate Course/ UFMG.

She supervised undergraduate, master and PhD, and coordinates and collaborates in scientific projects, mainly in the area of ​​neuroinflammation, publishing the data in indexed international journals, besides chapters and book. She also supervises research projects about Neurosciences and education. She coordinates social AGERE Program (Group of Educational Actions Related to Epilepsy), which received a UFMG recognition as the best Program in the health area (2019). She is permanent member of graduate Program in Physiology and Pharmacology, Graduate Program in Neurosciences, and Professional Master's Program in Teaching Biology (PROFBIO / ICB / UFMG).