Acute administration of tramadol and tapentadol at effective analgesic and maximum tolerated doses causes hepato- and nephrotoxic effects in Wistar rats.

Bibliographic reference: 

Barbosa J., Faria J., Leal S., Afonso LP., Lobo J., Queirós O., Moreira R., Carvalho F., & Dinis-Oliveira RJ. (2017). Acute administration of tramadol and tapentadol at effective analgesic and maximum tolerated doses causes hepato- and nephrotoxic effects in Wistar rats. Toxicology. Jul 6: pii: S0300-483X(17)30181-6.